The Center for Game Science at the University of Washington focuses on solving hard world-scale problems that neither people nor computers alone can solve by themselves. We do this by discovering unique tech-enabled learning pathways that drastically accelerate human learning and mastery; and by developing self-adapting algorithms that optimize joint outcomes. The Center studies ways to engage and inspire people reaching their potential through team work and symbiotic collaboration with computational methods. We have produced scientific discovery games that enabled novices to publish numerous world class scientific discoveries, games that discover optimal learning pathways and can teach algebra to all elementary school learners, games that change academic mindset and enable people to be more persistent when facing an obstacle. We primarily focus domains of scientific discovery and K-12 education, and mental health. To achieve our goals, our research spans many fields of computer science including: data science, crowd-sourcing, computer games, machine learning, intelligent tutors, inductive logic programming, program synthesis, self-adapting HCI, and computer graphics.